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Other studies have also reached similar results, with Lambert and Hartsough (1998) finding tobacco dependence to be 40% in individuals with ADHD, compared to 19% for individuals without ADHD.[9] The reason why nicotine dependence affects patients with psychiatric disorders disproportionately higher is because people may attempt to self-medicate to alleviate symptoms of their mental disorders with nicotine

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due to an inefficient anti-oxidant response as observed in COPD lungs [21, 22], may lead to impaired mitochondrial structure and function due to impaired clearance or repair

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Key factors include: pH level: Pouches with a slightly higher pH can support quicker nicotine release